Vitruvian Man Lab Report Essay Example

Vitruvian Man Lab Report Essay Example Vitruvian Man Lab Report Paper Vitruvian Man Lab Report Paper Later on, around the year 1490, the artist and painter Leonardo Dad Vinci decided to keep examining about his Statement. His famous drawing consists on a man with straight arms and legs, inside a square that is inside a circle, the exactly same idea Of Vitreous. He showed that the ideal human body fitted precisely into both a circle and a square, and he thus illustrated the link that he believed existed between perfect geometric forms and the perfect UDF'(The British Library Board). According with Natalie Holdover the circle is shown as a divine symbol and the square as the earthly symbol. This idea relates to the ancient belief that the man was a tiny expression of the entire universe, which is now called microcosm. As a class, we were asked to test the validity of the Dad Vines Vitamin man. We recorded the information of everyone from the class, measuring the length of the outspread arms, the height, the distance from the elbow to the tip of the hand and the maximum width of the shoulders. Our goal was to discover it our emissions settled with the ideal humans proportion according to Dad Vines Vitamin man. Dad Vinci explained that for a human to have perfect proportions need to follow the next criteria: the length of the outspread arms needs to be equal to the height of the man, the distance from the elbow to the tip of the hand needs to be of the height of man, and the maximum width of the shoulders needs to be % of the height of the man. After going through this whole process got into a very concise conclusion, just two people in my class have the ideal human proportions. Hungary Ramirez and Maria Smiley are the only ones who fit into the three Of the Statements made by Dad Vinci and Vitreous. As is shown on table #1 and table #2, Handcar Ramies length Of the outspread arms is equal to her height; her distance from the elbow to the tip of her hand equals a % Of her height, same situation occurs on Maria Shimmies measurements. But on the third criteria you can see there is a difference between the maximum of their shoulders and their heights a difference of 1 CM. Even though their measurements have a difference of one CM. We can still say their proportions are idea, since we are account the uncertainties of 1. Several of my other classmates followed several criteria hut at the end they didnt fit exactly, for example as its shown on table #1 and table Amanda Kauffmann length of the outspread arms is equal to her height, and her distance from the elbow to the tip of her hand sis % of her height as well, but when it cones to the third criteria, the maximum width of the shoulders isnt a 1/4 of her height. The deterrence is about to 4 CM, which is an extremely small difference, since the maximum of her shoulders is about 39 CM and the of her height is about 43 CM. Evaluation: Due to the fact that the Dad Vines Vitamin man lab demonstrated failure on the past examinations, we can feel free to assume that many errors are shown in this experiment. The first error noticed is the fact that we measured everything With a small measuring tape instead of a big measuring tape, which didnt help since we were taller and bigger than the measuring tape, so we had to use two measuring tapes added together. Using a small measuring tape to find out these measurements ended being extremely inaccurate. After data collection we were not really sure if the numbers we got were real, and probably affected a lot on the way the exults came out. The lab activity validity started to be questionable now. By the time we were looking for the four measurements needed just one group of people from the class was using a measuring tape, the rest of the class were using two small ones (so they could have the same length). The way it worked was to put one in the top of the other and then add the numbers, which was hard for the person who was measuring since he didnt have enough hands to hold the small measuring tape in the bottom, in the middle (place in which both tapes were combined) and in the top. If one of the measuring tapes we were sing (top or bottom) moved a little bit, then the whole addition will change and the final result will end being inaccurate, A proposed solution to this error will be measure all of the quantities again with a big measuring tape, in this way, we could make sure that all of the measurements are more precise and that no movement of the person with the tape was going to affect on the validity of the research. Another error noticed is the fact that you can always make a mistake with the numbers and get confused, so maybe the numbers you got arent real. A great solution to this error will be measuring at least three times each of the four acquirement, Which at the end Will give us a more specific, secure, and valid answer. If we make another two measurements and we still get different numbers, we need to keep remaking this process until we start getting the same answer over and over again after repetitive results. Another big error was noticed on the width of the shoulders measurements specifically, since some people didnt know from which to which point it was, so in that way some people got a very inaccurate difference between this number and the 1/4 of the height off man. A good example that is shown is on table #1 ND table #2, were Sabina Classical and Alberta Gonzalez got a lot of difference between this two measurements. Sprains width of the shoulders is equal to 54 CM as is shown in the first table, and the % of the height of a mans equals to 39. In the other hand, Albertson measurements also had a huge difference between them. His width to the shoulders is equal to 65, and 1/4 to his height equals to 43, SO. After inspecting those numbers we can conclude that there is an error, since the rest of the students show on table #1 and table #2 do not have a difference higher than three CM between the numbers as both of this students had. This numbers are very inaccurate since the width of the shoulders and the % of the height are suppose to be exactly the same, and this is such a huge difference. A solution to this problem could be measuring the width of the shoulders and the of height of this students again, few still get such a huge difference between both numbers, then the solution could be measuring the four principles again for this two people, at least 3 or 4 times, until the numbers we get are much more accurate. One limitation observed was the fact that most of us, the students, are still in a transitory age, Which means we are still going through the process Of evildoing physically. Since we are not entirely developed we are not a secure source to prove if this statement is true or false. Our legs are not entirely developed yet either our arms or the rest of our body. Another limitation I found was the fact that we tested the validity on man and women, which variance wasnt explain on the theory. Men and women may not have the same proportions as just man. This affected the research because women composed most of the class, so there were only two men (Alberta and Luis). The last limitation founded was the fact that this research was made hundreds ND thousands years ago by Vitreous and Dad Vinci, but with evolution human sizes may have changes and the proportions may have also changed, this effect was also reflected in the lab results.

How to Indicate Unspoken and Indirect Discourse

How to Indicate Unspoken and Indirect Discourse How to Indicate Unspoken and Indirect Discourse How to Indicate Unspoken and Indirect Discourse By Mark Nichol What type of markers or emphasis should a writer give to signal that a character’s thoughts are unspoken? Though some people disagree, the consensus is that they should be enclosed in quotation marks as if they were said aloud: 1. â€Å"She surveyed the shambles of her room and thought, ‘Where do I start?’† This mode of what is known as unspoken discourse assumes that internally vocalized thoughts are a form of direct speech. â€Å"Unspoken discourse† is not to be confused with â€Å"indirect discourse,† which describes indirect speech, or paraphrase: 2. â€Å"She surveyed the shambles of her room and wondered, where should she start?† In this case, the person would not think, â€Å"Where should she start?† in those words, so the final phrase of the sentence is a paraphrase, not a quote, and should not be enclosed in quotation marks. Indirect discourse has another, similar form: 3. â€Å"She surveyed the shambles of her room and wondered where she should start.† Notice that in this example, a different type of paraphrase, a comma does not precede the thought, and no question mark punctuates this sentence, because it’s not a question. As I mentioned above, some writers prefer to omit quotation marks in unspoken discourse: 4. â€Å"She surveyed the shambles of her room and thought, Where do I start?† This style is also correct, but it requires greater attention from the reader, and it seems more trouble than it’s worth to distinguish between spoken thoughts and unspoken ones, especially in fiction. Employing italics is an alternative strategy for unspoken discourse, but this method is best used in internal dialogue, when a person is conversing with their alter ego, or with a disembodied entity such as a spirit, or perhaps a guiding force from within: â€Å"The voice seemed to resonate inside her: Go forth, and fear not.† Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Style category, check our popular posts, or choose a related post below:Writing Prompts 10150 Idioms About Roads and Paths50+ Words That Describe Animals (Including Humans)

Business paln for Arts cafe Essay Example | Topics and Well Written Essays - 750 words

Business paln for Arts cafe - Essay Example The plan purposes to help learners develop their skills in art and provide a relaxing environment for workers especially those in the financial institutions who often experience stress from the long hours of work and less time for recreation and entertainment. The Art Cafà © offers an opportunity for artists to sharpen their skills and a common discussion area for individuals having common interest in art to share ideas and explore the art industry. It will also serve snacks, coffee and tea beverages as refreshments to the visitors; this is based on a study confirming coffee and tea to be the highly consumed beverages. Employees at the cafà © will be middle-aged individuals with experience in art and coffee. The plan focuses its strengths on customers who love art and provision of quality coffee and tea as a means of overcoming the competition in the market. The business plan aims to promote the love for art by establishing an arts cafà © where individuals with interesting art can meet and share ideas. Thank

Analysis between Life and Death in Shanghai and woman at point zero Essay

Analysis between Life and Death in Shanghai and woman at point zero - Essay Example It’s an autobiography of the author herself. It is a tale of woman who had been struggling for survival, dignity between the authoritarian of the Cultural Revolution. Her crime was just her class backdrop and a enthusiasm to life. She got arrested in the late 1966 after the â€Å"The Red Guards† looted her house. The book tells the story of Nien Cheng, when she got arrested all through the Cultural Revolution and was caught up in jail for more than six years. She was pressurized to accept the fake accuse that she was a spy for â€Å"the imperialists†. She refused to do so and lived a life in prison, full of misery and torture. Finally, she was released in 1973 and found out that her daughter, Meiping, who was going to school to become an actress was also murdered by â€Å"The Red Guards†, although, police told her that she has committed suicide. Cheng found this by investigating herself, and thought that the whole situation which was told by the police was impossible. Later she got relocated towards a two bedrooms apartment with one of her relative. Till 1980, Cheng lived in China than she moved towards United States. (Cheng, Nein., 1987). On the other hand, the book Women at Point Zero is written by Nawal El Saadawi. It is story which is based on the life of a woman namely, Firdaus. She is an ex-prostitute and was accused for the murder of a pimp. She refuses to talk to anyone in or out of the prison. However, Firdaus, agreed to talk with the author, who is a psychologist as well, on the tenth day of living in the prison. Gradually, she tells the author about the history of her life. In past, Firdaus life was full of abuse, abandonment, oppression, people taking advantage of her and people whom she met nearly rejected her from child to the adulthood. She was born in a farming society to an offensive father. Foremost important thing in the book is that Firdaus describes pleasure similar to pain and pain which is same like pleasure. After her parents

Proteins Therapy for Drug Discovery

Proteins Therapy for Drug Discovery Proteins are most dynamic and diverse macromolecules in our body, thus numerous functionally distinct proteins hold enormous promise for the development of new therapeutics for a variety of human ailments which contain mutated or other abnormal proteins, or those in an abnormally high or low concentration. However, the clinical application of protein therapeutics is still in its infancy since the poor physicochemical stability of proteins in the circulation and their limited membrane permeability interrupt successful delivery to the target sites. This review discusses advantages and limitations of current strategies, as well as the recent developments in protein delivery using nanoparticles. We also highlight nanoparticle-mediated alternative administration routes to injection, including oral, nasal, pulmonary, and transdermal delivery. Keywords: nanoparticles, protein delivery, protein therapeutics, administration routes, drug delivery systems Introduction With the strong growth in biopharmaceuticals and advanced drug delivery technologies in recent years, pharmaceutical companies are increasingly turning toward protein therapeutics in the search for drug discovery targets. A study by BCC Research indicated that the global market for bioengineered protein drugs was valued at $151.9 billion in 2013 and the market is further expected to grow to about $222.7 billion in 2019 for a compound annual growth rate (CAGR) of 7.2% from 2014 through 2019 [1]. Compared with the conventional small-molecule drugs that currently make up the majority of the pharmaceutical market, protein drugs offer the advantages of high specificity and less toxicity, whereas the high specificity often requires structural complexity of the proteins which can make them difficult to formulate, as well as challenging to deliver proteins to target disease sites. Nanotechnology-based approaches, including drug delivery systems using nanostructures such as liposomes, polymer nanoparticles, metallic nanoparticles, stimuli-responsive nanoparticles, and nanofabricated devices, has improved therapeutics in the field of biomedical applications [2,3]. This review describes current protein delivery technologies including those in the market, recent progress, and unmet needs in the formulations and delivery of proteins. The advances in nanotechnology reviewed here highlight that major hurdles in protein delivery can be met even through the patient-friendly, non-invasive routes. Progress and challenges in protein delivery To achieve successful protein therapeutics, the intrinsic characteristics of proteins such as structural instability and short half-life should be improved by designing appropriate protein delivery platforms. Inadequate design or formulation of protein drugs can cause degradation, denaturation, and/or aggregation of the protein molecules, and these could potentially cause immunogenic side effects after administration as well as lead to a loss in pharmacological activity. Effective intracellular protein delivery also remains a challenge as hydrophilic and large sizes of proteins are hardly permeated through the cell membrane. In this section, current technologies to deliver proteins, including intracellular delivery strategies, and their limitations will be discussed. Current protein formulations and modifications Biodegradable microparticles (1-1000 à ¯Ã‚ Ã‚ ­m) are attractive parental depot formulations for long-term protein drug release (from week to month). They enable sustained release of the proteins by both the diffusion of proteins from the polymer matrix and the degradation/erosion of the polymer [4,5]. The most widely used material for the encapsulation of proteins is poly(lactic-co-glycolic acid) (PLGA), as they are mechanically strong, biocompatible, biodegradable with favorable degradation rates, non-toxic, and approved for use in humans by the US Food and Drug Administration (FDA) [6]. Encapsulation of proteins into the microparticles can be prepared by several methods such as double emulsion, which is most widely used technique, phase separation (coacervation), ultrasonic atomization, spray-drying, microfluidics, etc. [7]. Once the proteins are encapsulated into microparticles, their release kinetics depend on the microparticle size, molecular mass of polymer, ratio of hydroph ilicity/hydrophobicity, polydispersity of microparticle size, and loading amount of proteins. Generally, larger size of microparticles lead to more prolonged protein release, but they can cause potential blockage of the needle required for administration, also the stability and bioactivity of the released proteins in the physiological condition need to be considered for long-term delivery. Degradation and erosion of PLGA can lower the pH inside the microparticles, which can further bring denaturation of the protein as well as aggregate formation. Currently, there are few microparticle drug delivery formulations (e.g. Trelstar depot) on the market and various microparticles have been designed for therapeutic protein delivery such as bone morphogenetic protein-2 [8], insulin [9], recombinant human epidermal growth factor [10], and recombinant human erythropoietin (EPO) [11]. Proteins smaller than 70 kDa are mostly cleared from the systemic circulation by glomerular filtration [12]. Chemical modification of proteins with hydrophilic polymers can reduce this renal clearance by increasing their molecular weight and/or hydrodynamic dynamic radius. The covalent attachment of polyethylene glycol (PEG) chains to proteins (PEGylation), as a typical example, enhances protein stability and pharmacokinetic (PK) properties, and the benefits of PEGylation have the PEGylated therapeutic proteins have reached the market with many examples on various stages of clinical development including Naloxegol (MovantikTM; AstraZeneca) which was approved by FDA in 2014 for the treatment of opioid-induced constipation [13,14]. Hyperglycosylation can also extend biological half-life and improve stability by improving solubility of proteins and reducing immunogenicity. The addition of sugar molecules to a protein is more natural process than PEGylation since it is already a part of endogenous post-translational enzymatic process as well as polysaccharides are readily degraded into native glucose molecules [15]. N-glycosylated EPO (Aranesp) is marketed by Amgen from 2001, and there are more glycosylated protein drugs under preclinical and clinical investigation such as polysialylated forms of EPO, granulocyte-colony stimulation factor (G-CSF), and insulin [16]. Although the chemical modification provides the prolonged circulation half-life of the proteins, this approach can result in unfavorable conformational changes, a loss of biological activity and binding affinity to their target due to steric hindrance, and heterogeneity [17]. This reduction in physicochemical properties leads to the systemic exposure of proteins to get enough pharmacological potency, but toxicities related to peak exposure can limit their clinical use. Various efforts aiming for the maintenance of protein activity are being made by designing site-specific modification. For example, chemi cal ligation of synthetic peptides including levulinyllysine to EPO indicated superior hematopoietic activity compared to native protein [18]. More recent advances in chemoselective targeting show that the incorporation of canonical and noncanonical amino acids can enhance the selectivity, while improving PEG architecture [19]. In addition to chemical modification, genetic constructs and fusion technologies have been intensively studied to elevate protein half-life and delivery efficacy. Fc-based fusion proteins that are composed of an immunoglobin Fc domain and genetically linked therapeutic protein to this domain are promising approaches as Fc-fusion can endow a protein with unique effector functions mediated by Fc receptor binding and complement fixation [20]. The neonatal Fc receptor (FcRn) mediated recycling and transcytosis process results in half-life extension (e.g. IgG: up to 21 days) and also the increased molecular weight of fusion proteins through the size of the Fc-domain (~50 kDa) reduces renal clearance [21]. A number of therapeutic proteins based on fusion with the IgG Fc domain are on the market for clinical use since Fc-fused tumor necrosis factor (TNF) receptor-2 (Enbrel; Amgen/Pfizer) was approved for the treatment of rheumatoid arthritis and plaque psoriasis in 1998, and several candida tes are currently under clinical trials [22]. Recent Fc-fusion platforms focus on the ways to retain biological activity and binding affinity which can be commonly decreased after fusion process [23,24]. Jung et al. included a ‘chaperone’ protein in Toll-like receptor 4 Fc-fusion to stabilize the desired partner [25]. The development of heterodimeric Fc platforms based on strand-exchange engineered domain CH3 heterodimers consisted of alternating segments of human IgA and IgG CH3 shows multiple specificities within homodimeric Fc-fusion platform [26]. To utilize alternative backbones, such as IgA, IgE, and IgM, may also serve benefits to the activity of the fused partner [27-29]. However, concerns are ongoing about the immunogenicity of Fc-fusion proteins because interactions between the Fc domain and its receptors have multivariable immunological consequences, which can raise concerns in the treatment for chronic disease [30]. Other attempts to target FcRn including al bumin fusion which has direct interaction with FcRn and genetic engineering of Fc domains have also been reported. A glucagon-like peptide-1 (GLP-1) albumin fusion achieved ~ 5 day half-life and received FDA-approval (Albiglutide; GSK) for the treatment of type-2 diabetes [31]. A recombinant polypeptide fusion construct which consists of an unstructured polypeptide and protein drug is another example of generic fusion technology capable of extending plasma half-life. Schellenberger et al. developed an exenatide-XTEN fusion and demonstrated ~58 times increased half-life and a low rate of immunogenicity in animals, even in the presence of the adjuvant [32]. Still, issues remain in safety of fusion approaches, in particular in the case of fusions with native human proteins because of the cross-reactivity with endogenous homologues which can affect on a long-term safety and clearance of subsequent doses [33].

Greek Mythology Newspaper Headlines

Hello, this is the most exquisite goddess of love and beauty, here to do my beloved job of creating love. So, this week we have advice for the lovely queen of the gods as she requested, but as she would rather not have her true name revealed, she asked to be called CheatedWife1 instead. Now, CheatedWife1, you have come to me saying that your husband Zeus, king of the gods, is a cheater and is always fraternizing with other women, mortal and divine. I must say, this is quite a sad revelation! Well, my advice to you is to try to catch these consorts, and show them just who is queen of the gods and rightful consort of Zeus! That’s it for today so see you next week with another section of advice! May love find you quickly! -AphroditeOlympus NewsThis week on Olympus, we have visiting the mortal Hercules, who will be attending the company of Lady Hera, as he was summoned. Hercules has been a wonder to the mortals, and a source of revenge for the Lady Hera because her husband Zeus is his father, and she isn’t the mother. His many extraordinary feats include: slaying the Nemean Lion, slaying the Hydra, capturing the Erymanthian Boar, slaying the Stymphalian Birds, capturing the Cretan Bull, obtain the cattle of the monster Geryon, steal the apples of the Hesperides, capture and bring back Cerubus, and many more so make sure to respect this mighty hero! Mortal NewsThis week the mortals have been involved in yet another war, one they call the Trojan War because the opposing sides are the city of Troy and the Greeks. Troy had managed to hide behind its high and protective walls for a long while, but eventually the Greeks broke through by sending a small force in the guise of a large wooden horse that they hid inside, then from there allowed the rest of their army entry and took down Troy. It has been confirmed that divine interference was the base cause of this war, although names will not be said in order to avoid a godly war. In other news the demigod Pers eus has managed to slay the hideous gorgon Medusa and take her head, a marvelous victory, for a mortal.SportsAs many of us gods and goddesses are already aware, the Olympic Games are approaching. The mortals have made this a religious event, and will pray to us for our help, but just a reminder: we must not interfere with these games as they are dedicated to Mighty Zeus and so he has decreed such. These games started with finding a priestess for the Lady Hera, but eventually became the event that involves both the mortals and us deities.

How did UK and US relations change after the election of Obama - Free Essay Example

Sample details Pages: 8 Words: 2361 Downloads: 7 Date added: 2017/06/26 Category Politics Essay Type Analytical essay Did you like this example? In his 1946 Iron Curtain speech, Winston Churchill (2015, n. pag.) stated that [n]either the sure prevention of war, nor the continuous rise of world organisation will be gained without what I have called the fraternal association of the English-speaking peoples. This means a special relationship between the [UK] and the United States. The end of World War II did indeed mark the start of a special relationship between the two nations and it has been characterised by political, diplomatic, economic and military relations as well as shared values and strategic objectives in the intervening years (Wallace Phillips, 2009). Don’t waste time! Our writers will create an original "How did UK and US relations change after the election of Obama?" essay for you Create order However, there has been significant coverage and analysis of the special relationship since the 2008 election of Barack Obama as US President, with many political commentators, academics and journalists alike speculating as to how relevant such a relationship may now be as a result of changing strategy on the part of both nations. This essay will establish the state of the special relationship between the UK and the United States prior to the election of Barack Obama before exploring the political, economic and social changes that occurred in the wake of his inauguration. This will be done with a view to concluding that 2008 was a watershed for the special relationship as a result of changing US and UK priorities, transitional leadership and the global financial crisis. However, despite the evolution of the special relationship as a result of a shifting global political and economic climate, it is still a key strategic alliance that is relevant to the security of both states and the international community as a whole today. Prior to 2008, the special relationship between the UK and US had the purpose of forming close cooperation between the two in terms of nuclear weapons technology, economic activity, trade and military planning and execution, amongst other areas (Wither, 2006). In the immediate aftermath of World War II, it forged a mutual recovery and support in the rebuilding of states that had been damaged by the war with the added point of America becoming the global leader (Arnold, 2014; Friedman, 2007). Lee (2010) argues that the UK was the weaker partner throughout the second half of the 20th century was a result of the fact that the defence cooperation between the two was dominated by the US, who had larger strategic forces and often demanded UK cooperation in initiatives during the Cold War. Wright (2002) supplements this perspective and notes that this imbalance persisted into the 21st century as a result of the UKs backing of George W. Bushs act ions in the wake of 9/11 in exchange for maintaining British influence internationally. The British support for US foreign and security policy in the aftermath of 9/11, particularly the 2003 invasion of Iraq, suggested that the special relationship remained strong despite the fact that it did not have popular support in Britain and raised significant questions as to whether it was in the best interests of the UK to follow American international strategy (Dumbrell, 2009). However, regardless of the controversy that surrounded the actions of both nations, there can be little doubt that there were strong political, strategic and military links in place prior to the election of Obama in 2008. Following Obamas election in 2008, the special relationship has been called into question as a direct result of the ideological disparities between the new President and his predecessor. Obamas diplomatic objectives and strategic goals departed significantly from the approach taken towards allia nces and security by George W. Bush. For example, Dumbrell (2009) notes that Obama had an ambivalence towards the protectionist strategy that had previously been employed and those applying pressure on the president to continue to pursue it as well as committing to diplomacy with other European states to encourage engagement in Afghanistan. As such, the foundation of the special relationship had become distorted as a direct result of the fact that Obama did not wish to prioritise relations with Britain in order to secure an ally in the international community based on a traditional mutual need. Indeed, both Gordon Brown and Barack Obama sought to address global issues like climate change (Dumbrell, 2013) and the restructuring of international institutions to create an effective and efficient global society (Dumbrell, 2008). These issues were not prioritised on Bushs agenda and the cooperation between the US and UK on them provides evidence of a shift in focus. However, the fact that both pledged to cooperate on matters of international rather than domestic importance does underscore the fact that diplomatic and political relations were still in place despite Obamas determination to redefine US foreign policy. As such, the special relationship did change in the field of diplomacy but remained resolutely in place. In highlighting Obamas tentative departure from the traditional American protectionist stance, Dumbrell (2009) also drew attention to the fact that Obama sought to build military alliances to strengthen his position in Afghanistan and this also impacted upon that particular aspect of the special relationship. For example, Self (2010) states that Obama exerted pressure on the British government into committing more troops to the ongoing war in Afghanistan. This was done via coercive rhetoric in a bid to overcome policy differences that were geared towards protecting the British national interest in a time of economic crisis. As such, there was signif icant conflict in the area of military cooperation because of the circumstances that had changed the priorities of both nations. The military element of the special relationship also evolved after the inauguration of Obama in other ways that were directly linked to the shift in American strategic priorities (Wither, 2006). For example, Wither (2006, p. 47) argues that: the longstanding defence partnership is threatened by a number of factors, including interoperability problems, the UKs national and defence spending priorities, the likely impact of a decision to replace Trident and the decline in the importance of the transatlantic strategic partnership in NATO. This identifies several areas where US priorities were distinctly different to those of the UK and therefore marks a major disjunction between the policies of both. This had not existed before as the UK had actively supported the US in its global endeavours, often without question (Dumbrell, 2009). There can be no doub t that the UK was not able to do so to the same extent after 2008. British military capabilities were significantly reduced in the wake of the 2008 global financial crisis, which raised significant questions about the UKs ability to contribute to global security as well as compromising any future usefulness in collaborative overseas operations (Wither, 2006). This was also paired with a reluctance to aid Obama via bilateral agreements to take action overseas, with a prime example being parliaments rejection of Prime Minister David Camerons proposal to ally with Obama and commit to air strikes in Syria in 2013 and the resultant strained relationship between the two leaders (Rothkopf, 2014). As a consequence, the special relationship had fundamentally changed in numerous ways based upon the reluctance of the UK to tow the American line and the frustration that manifested in the military relationship between the two, at least on a governmental level if not on the ground where cooperati on did occur. Although cooperation may not have been as forthcoming in a military context as it had been prior to 2008, there are areas of policy and the special relationship in which new forms of cooperation flourished. For example, according to Wallace and Phillips (2009, p, 263), the US-UK special relationship today has a political and ideological superstructure and an embedded military and intelligence substructure. This suggests that there is active cooperation between the two in the intelligence sphere and that is reinforced by the creation of a National Security Strategy Board, which was designed to provide a clear line of communication between officials in the UK and the US to discuss security and strategy as and when necessary (Watt, 2011). In addition, there are ongoing intelligence operations that require cooperation between the two, most notably the running of CIA networks within British communities in conjunction with MI5 in order to prevent terrorist attacks (Svends on, 2010). In effect, stronger links have developed in this particular area of the relationship and illuminate how it has changed based upon need. The economic aspect of the special relationship also demands scrutiny. Despite the global economic crisis that damaged both the US and UK economies significantly there is extensive economic activity that ties them together, including trade and investment that renders each the largest investor in the other (Foreign Affairs Committee, 2010). This irrevocably bound the nations together and provided a point of cooperation that was seemingly unaffected by global goals as it benefitted both nations. Indeed, Stacey et al (2015, n. pag.) note that Obama perceived the US and UK economies as the two that were standing out at a time when a lot of other countries are having problems at the beginning of 2015, thus ostensibly reaffirming the special relationship publically. The implication here is that the strength of both economies reinforced the r elationship as a result of the ongoing benefits that both nations were able to reap from the situation. It should be noted that there were points of disagreement, such as the fact that Obama sought to insert clauses into World Trade Organisation UK stimulus packages that were designed to protect American industry and jobs. However, these did not actively impact upon the economic support or cooperation that one provided the other. In effect, this particular area of the special relationship changed very little despite the global economic climate and the uncertainty it introduced impacting upon other areas. However, despite the changes to the special relationship illustrated above, there are certain elements of it that have altered little since 2008. For example, despite the fact that Obama has favoured a partnership with the collective of European states rather than one nation, the UK is still the weaker partner in the relationship: relief that [Obamas] first phone call to a Europe an leader was to Gordon Brown, indicates how dependent Britains claim to global status is on Washingtons approval (Wallace Phillips, 2009, p. 283). Although the UK is no longer a bridge to Europe as a result of Obamas desire to establish relationships with the European Union and its individual states (Cameron, 2007), it still maintains the closest relationship of all European states to the US and continues to be its closest ally. This is important in determining how far the special relationship had changed and denotes the presence of common ground that has endured from the end of World War II and is still in place. In conclusion, the analysis in this essay points to the special relationship between the UK and United States undergoing a fundamental change in the wake of the election of President Barack Obama in 2008. Although the channels of communication remained open and were consolidated as a result of cooperation in the field of intelligence and via the new National Security Strategy Board, the strategic goals of both nations were undoubtedly impacted by economic crisis, involvement on a changing international stage and the need to develop enhanced relations with other European nations. There is also evidence of friction between the two nations and this manifests in an unwillingness to support the other unless initiatives and policies were also in the national interest. These points outline how the special relationship changed on an ideological and a practical level. However, the economic element of the special relationship remained intact, in spite of the attempts by the US government to insert clauses into stimulus agreements to aid the American economy, and this underlined the remaining importance of each power to the other. As such, the analysis reinforces the idea that 2008 was a watershed for the US-UK special relationship as a result of the impact that changing priorities, transitional leadership and the global financial crisis had on both nation s. There has certainly been a need for the evolution of the special relationship as a result of a shifting global political and economic climate but the relations between the US and UK still facilitate the maintenance of a key strategic alliance that is relevant to the security of both states and responds to the demand for global leadership by the international community today. Bibliography Arnold, G., (2014). America and Britain: Was There Ever a Special Relationship. London: C. Hurst Co. 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